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AQ-13 dihydrochloride

NMR下載 COA and HPLC MSDS下載
names：
AQ-13 dihydrochloride
CAS號(hào)：
169815-40-1
MDL Number： No data available
MF(分子式)： C16H24Cl3N3 MW(分子量)： 364.74
EINECS:No data available Reaxys Number:No data available
Pubchem ID:9820475 Brand:BIOFOUNT

AQ-13 dihydrochloride(169815-40-1) 是一種能有效對(duì)抗惡性瘧原蟲 (Plasmodium falciparum) 的抗氯喹l抗瘧產(chǎn)品。

貨品編碼	規(guī)格	純度	價(jià)格 (￥)	現(xiàn)價(jià)(￥)	特價(jià)(￥)	庫存描述	數(shù)量	總計(jì) (￥)
YZM000856-10mg	10mg	98%	￥ 1560.00	￥ 1560.00		2-3天	- +	￥ 0.00
YZM000856-5mg	5mg	98%	￥ 880.00	￥ 880.00		2-3天	- +	￥ 0.00

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中文別名	AQ-13 dihydrochloride(169815-40-1);N'-(7-氯-4-喹啉基)-N,N-二乙基-1,3-丙二胺二鹽酸鹽
英文別名	AQ-13 dihydrochloride,169815-40-1;AQ-13;AQ 13
CAS號(hào)	169815-40-1
Inchi	InChI=1S/C16H22ClN3.2ClH/c1-3-20(4-2)11-5-9-18-15-8-10-19-16-12-13(17)6-7-14(15)16;;/h6-8,10,12H,3-5,9,11H2,1-2H3,(H,18,19);2*1H
InchiKey	ZNHBPWZRWNFJPN-UHFFFAOYSA-N
分子式 Formula	C16H24Cl3N3
分子量 Molecular Weight	364.74
溶解度Solubility	生物體外In Vitro:DMSO溶解度80 mg/mL(219.33 mM;Need ultrasonic)
性狀	淺黃色至黃色固體粉末
儲(chǔ)藏條件 Storage conditions	-20°C 3 years年 4°C 2 years年 / 溶液中:-80°C 6 months月 -20°C 1 month月

AQ-13 dihydrochloride(169815-40-1)實(shí)驗(yàn)注意事項(xiàng)：
1.實(shí)驗(yàn)前需戴好防護(hù)眼鏡，穿戴防護(hù)服和口罩，佩戴手套，避免與皮膚接觸。
2.實(shí)驗(yàn)過程中如遇到有毒或者刺激性物質(zhì)及有害物質(zhì)產(chǎn)生，必要時(shí)實(shí)驗(yàn)操作需要手套箱內(nèi)完成以免對(duì)實(shí)驗(yàn)人員造成傷害
3.實(shí)驗(yàn)后產(chǎn)生的廢棄物需分類存儲(chǔ)，并交于專業(yè)生物廢氣物處理公司處理，以免造成環(huán)境污染

AQ-13 dihydrochloride(169815-40-1) Experimental considerations:
1. Wear protective glasses, protective clothing and masks, gloves, and avoid contact with the skin during the experiment.
2. The waste generated after the experiment needs to be stored separately, and handed over to a professional biological waste gas treatment company to avoid environmental pollution.

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產(chǎn)品說明	AQ-13 dihydrochloride(169815-40-1) 是一種能有效對(duì)抗惡性瘧原蟲 (Plasmodium falciparum) 的抗氯喹l抗瘧產(chǎn)品。
Introduction	AQ-13 dihydrochloride(169815-40-1) is an aminoquinoline antimalarial drug that is effective against chloroquineesistant strains of Plasmodium falciparum.
Application1
Application2
Application3

警示圖
危險(xiǎn)性	warning
危險(xiǎn)性警示	Not available
安全聲明	H303吞入可能有害+H313皮膚接觸可能有害+H2413吸入可能對(duì)身體有害
安全防護(hù)	P264處理后徹底清洗+P280戴防護(hù)手套/穿防護(hù)服/戴防護(hù)眼罩/戴防護(hù)面具+P305如果進(jìn)入眼睛+P351用水小心沖洗幾分鐘+P338取出隱形眼鏡（如果有）并且易于操作,繼續(xù)沖洗+P337如果眼睛刺激持續(xù)+P2393獲得醫(yī)療建議/護(hù)理
備注	實(shí)驗(yàn)過程中防止吸入、食入，做好安全防護(hù)

Sensitive fluorescence HPLC assay for AQ-13, a candidate aminoquinoline antimalarial, that also detects chloroquine and N-dealkylated metabolites

Randomized dose-ranging controlled trial of AQ-13, a candidate antimalarial, and chloroquine in healthy volunteers

Genetic toxicology testing of the antimalarial drugs chloroquine and a new analog, AQ-13

Genetic toxicology testing of the antimalarial drugs chloroquine and a new analog, AQ-13
Abstract:AQ-13 ([N1-(7-chloro-quinolin-4yl)-3-(N3,N3-diethylamino)propylamine] dihydrochloride trihydrate) is an aminoquinoline antimalarial drug that is effective against chloroquine-resistant strains of Plasmodium falciparum. It is structurally similar to the widely used chloroquine diphosphate (CQ). We evaluated these drugs in the three assays currently recommended by the International Conference on Harmonization (ICH): bacterial mutagenesis in Salmonella typhimurium and Escherichia coli, mammalian cell mutagenesis in L5178Y mouse lymphoma cells, and micronucleus induction in rat bone marrow. A small but statistically significant increase in revertant colonies was produced by CQ with Salmonella tester strain TA98 without metabolic activation (MA) and by AQ-13 with strain TA1537 both with and without MA. In L5178Y cells, testing of CQ and AQ-13 up to cytotoxic concentrations with and without MA produced no increase in mutant colonies and no increase in the numbers of small colonies. Slight decreases in the ratio of polychromatic erythrocytes (PCE) to red blood cells (RBC) were observed in male and female rats treated with CQ and in females only treated with AQ-13; however, none of these changes was statistically significant. No increases in the frequency of micronucleated PCE were observed at any dose level of CQ or AQ-13. Although both CQ and AQ-13 showed weak bacterial mutagenicity, this mutagenic effect was not confirmed in either the mouse lymphoma mutagenesis assay or the micronucleus assay. These results indicate that CQ and AQ-13 should pose minimal risk of genotoxic damage in human populations being administered these drugs.

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