阿托伐醌

NMR下載 COA and HPLC MSDS下載
names：
Atovaquone
CAS號：
95233-18-4
MDL Number： MFCD00889188
MF(分子式)： C22H19ClO3 MW(分子量)： 366.84
EINECS:NA Reaxys Number:NA
Pubchem ID:67544 Brand:BIOFOUNT

阿托伐醌(Atovaquone,95233-18-4) blocks the mitochondrial electron transport at complex III of the respiratory chain of protozoa, thereby inhibiting pyrimidine synthesis, preventing DNA synthesis and leading to protozoal death.

貨品編碼	規格	純度	價格 (￥)	現價(￥)	特價(￥)	庫存描述	數量	總計 (￥)
YZM000765-50mg	50mg	>98.0%	￥ 1883.00	￥ 1883.00		2-3天	- +	￥ 0.00
YZM000765-10mg	10mg	>98.0%	￥ 585.00	￥ 585.00		2-3天	- +	￥ 0.00

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中文別名	阿托伐醌(Atovaquone,95233-18-4);阿托喹酮(標準品);2-(反式-4-(4-氯苯基)環己基)-3-羥基-1,4-萘二酮;阿托喹酮;阿托伐醌;阿托伐醌 -D4
英文別名	Atovaquone(阿托伐醌,95233-18-4);3-[4-(4-Chlorophenyl)cyclohexyl]-4-hydroxy-1,2-naphthalenedione
CAS號	95233-18-4
Inchi	InChI=1S/C22H19ClO3/c23-16-11-9-14(10-12-16)13-5-7-15(8-6-13)19-20(24)17-3-1-2-4-18(17)21(25)22(19)26/h1-4,9-13,15,24H,5-8H2
InchiKey	BSJMWHQBCZFXBR-UHFFFAOYSA-N
分子式 Formula	C22H19ClO3
分子量 Molecular Weight	366.84
溶解度Solubility	Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
性狀	固體粉末,Power
儲藏條件 Storage conditions	-20°C 3 years年 4°C 2 years年 / In solvent溶液中:-80°C 6 months月 -20°C 1 month月

阿托伐醌(Atovaquone,95233-18-4)實驗注意事項：
1.實驗前需戴好防護眼鏡，穿戴防護服和口罩，佩戴手套，避免與皮膚接觸。
2.實驗過程中如遇到有毒或者刺激性物質及有害物質產生，必要時實驗操作需要手套箱內完成以免對實驗人員造成傷害
3.實驗后產生的廢棄物需分類存儲，并交于專業生物廢氣物處理公司處理，以免造成環境污染Experimental considerations:
1. Wear protective glasses, protective clothing and masks, gloves, and avoid contact with the skin during the experiment.
2. The waste generated after the experiment needs to be stored separately, and handed over to a professional biological waste gas treatment company to avoid environmental pollution.

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產品說明	阿托伐醌(Atovaquone,95233-18-4)是具有抗原生動物活性的合成羥基萘醌。
Introduction	Atovaquone(阿托伐醌,95233-18-4) is a synthetic hydroxynaphthoquinone with antiprotozoal activity.
Application1
Application2
Application3

警示圖
危險性	warning
危險性警示	Not available
安全聲明	H303吞入可能有害+H313皮膚接觸可能有害+H2413吸入可能對身體有害
安全防護	P264處理后徹底清洗+P280戴防護手套/穿防護服/戴防護眼罩/戴防護面具+P305如果進入眼睛+P351用水小心沖洗幾分鐘+P338取出隱形眼鏡（如果有）并且易于操作,繼續沖洗+P337如果眼睛刺激持續+P2393獲得醫療建議/護理
備注	實驗過程中防止吸入、食入，做好安全防護

Repurposing old drugs as antiviral agents for coronaviruses Biomedical journal/PMID: 32563698

Coronavirus disease 2019 drug discovery through molecular docking F1000Research/PMID: 32704354

Inhibition by atovaquone of CYP2C9-mediated sulphamethoxazole hydroxylamine formation European Journal of Clinical Pharmacology/PMID: 29687367

Atovaquone enhances doxorubicin’s efficacy via inhibiting mitochondrial respiration and STAT3 in aggressive thyroid cancer Journal of Bioenergetics and Biomembranes 2018/PMID: 31912250

Atovaquone/proguanil for the treatment and prevention of malaria Current Infectious Disease Reports 2001

Coronavirus disease 2019 drug discovery through molecular docking

Abstract：

Background: The dawn of the year 2020 witnessed the spread of the highly infectious and communicable disease coronavirus disease 2019 (COVID-19) globally since it was ?rst reported in 2019. Severe acute respiratory syndrome coronavirus-2 is the main causative agent. In total, 3,096,626 cases and 217,896 deaths owing to COVID-19 were reported by 30th April, 2020 by the World Health Organization. This means infection and deaths show an exponential growth globally. In order to tackle this pandemic, it is necessary to ?nd possible easily accessible therapeutic agents till an effective vaccine is developed.

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