阿維菌素B1

NMR下載 COA and HPLC MSDS下載
names：
Avermectin B1
CAS號：
71751-41-2
MDL Number： MFCD01939385
MF(分子式)： C95H142O28 MW(分子量)： 1732.13
EINECS:265-610-3 Reaxys Number:NA
Pubchem ID:6434889 Brand:BIOFOUNT

阿維菌素(Avermectin B1,71751-41-2);外觀為淡黃色至白色結晶粉末，無味。阿維菌素是由日本北里大學大村智等和美國Merck公司首先開發的一類具有殺蟲、殺螨、殺線蟲活性的十六元大環內酯化合物，由鏈霉菌中灰色鏈霉菌Streptomyces avermitilis發酵產生。

貨品編碼	規格	純度	價格 (￥)	現價(￥)	特價(￥)	庫存描述	數量	總計 (￥)
YZM000762-200mg	200mg	>97.0%	￥ 0.00	￥ 0.00		Backorder	- +	￥ 0.00
YZM000762-100mg	100mg	>97.0%	￥ 341.25	￥ 341.25		2-3天	- +	￥ 0.00

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中文別名	阿維菌素(Avermectin B1,71751-41-2)；阿佛菌素;白螨凈;殺蟲素;阿維菌素
英文別名	Avermectin B1(阿維菌素,71751-41-2)；Avermectin; Baimianjing; Insecticidal; Avermectin
CAS號	71751-41-2
Inchi	InChI=1S/C48H72O14/c1-11-25(2)43-28(5)17-18-47(62-43)23-34-20-33(61-47)16-15-27(4)42(26(3)13-12-14-32-24-55-45-40(49)29(6)19-35(46(51)58-34)48(32,45)52)59-39-22-37(54-10)44(31(8)57-39)60-38-21-36(53-9)41(50)30(7)56-38/h12-15,17-19,25-26,28,30-31,33-45,49-50,52H,11,16,20-24H2,1-10H3/b13-12+,27-15+,32-14+/t25-,26-,28-,30-,31-,33+,34-,35-,36-,37-,38-,39-,40+,41-,42-,43+,44-,45+,47+,48+/m0/s1
InchiKey	RRZXIRBKKLTSOM-XPNPUAGNSA-N
分子式 Formula	C95H142O28
分子量 Molecular Weight	1732.13
溶解度Solubility
性狀	固體粉末,Power
儲藏條件 Storage conditions	-20°C 3 years年 4°C 2 years年 / In solvent溶液中:-80°C 6 months月 -20°C 1 month月

阿維菌素(Avermectin B1,71751-41-2)毒性：

生物	測試類型	路線	報告劑量（標準化劑量）	影響	參考
bird - domestic	LD50	unreported	> 2gm/kg (2000mg/kg)		Defense des Vegetaux. Vol. 42(249-250), Pg. 41, 1988.
duck	LD50	unreported	84600ug/kg (84.6mg/kg)		Defense des Vegetaux. Vol. 42(249-250), Pg. 41, 1988.
monkey	LD50	oral	17mg/kg (17mg/kg)		Defense des Vegetaux. Vol. 42(249-250), Pg. 41, 1988.
mouse	LD50	intracrebral	1740ug/kg (1.74mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD	Toxicology Letters. Vol. 60, Pg. 289, 1992.
mouse	LD50	oral	13600ug/kg (13.6mg/kg)		Defense des Vegetaux. Vol. 42(249-250), Pg. 41, 1988.
rabbit	LD50	skin	> 2gm/kg (2000mg/kg)		Defense des Vegetaux. Vol. 42(249-250), Pg. 41, 1988.
rat	LC50	inhalation	1100mg/m3/4H (1100mg/m3)		Defense des Vegetaux. Vol. 42(249-250), Pg. 41, 1988.
rat	LD50	oral	10mg/kg (10mg/kg)		"Merck Index; an Encyclopedia of Chemicals, Drugs, and Biologicals", 11th ed., Rahway, NJ 07065, Merck & Co., Inc. 1989Vol. 11, Pg. 3, 1989.

阿維菌素(Avermectin B1,71751-41-2)實驗注意事項：
1.實驗前需戴好防護眼鏡，穿戴防護服和口罩，佩戴手套，避免與皮膚接觸。
2.實驗過程中如遇到有毒或者刺激性物質及有害物質產生，必要時實驗操作需要手套箱內完成以免對實驗人員造成傷害
3.實驗后產生的廢棄物需分類存儲，并交于專業生物廢氣物處理公司處理，以免造成環境污染Experimental considerations:
1. Wear protective glasses, protective clothing and masks, gloves, and avoid contact with the skin during the experiment.
2. The waste generated after the experiment needs to be stored separately, and handed over to a professional biological waste gas treatment company to avoid environmental pollution.

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產品說明	阿維菌素(Avermectin B1,71751-41-2):用于滅蚊. 阿維菌素B1a是阿維菌素。
Introduction	Avermectin B1(阿維菌素,71751-41-2)used for mosquito control.Avermectin B1a is an avermectin.
Application1	天然阿維菌素中含有8個組分，主要有4種即A1a、A2a、B1a和B2a，其總含量≥80%；對應的4個比例較小的同系物是A1b、A2b、B1b和B2b，其總含量≤20Chemicalbook%。目前市售阿維菌素農藥是以abamectin為主要殺蟲成分(AvermectinB1a+B1b，其中B1a不低于90%、B1b不超過5%)，以B1a的含量來標定。
Application2	自從1991年害極滅(abamectin)進入我國農藥市場以后，阿維菌素農藥在我國的害蟲防治體系中占有較重要地位。阿維菌素在我國目前有10余家企業生產，目前市售的阿維菌素系列農藥有阿維菌素、伊維菌素和甲胺基阿維菌素苯甲酸鹽。我國20世紀80年代末由上海市農藥研究所開發的從廣東揭陽土壤中分離篩選得到7051菌株，后經鑒定證明該菌株與S.avermitilisMa-8460相似，與阿維菌素的Chemi
Application3	阿維菌素對螨類和昆蟲具有胃毒和觸殺作用，不能殺卵。作用機制與一般殺蟲劑不同的是干擾神經生理活動，刺激釋放γ-氨基丁酸，而氨基丁酸對節肢動物的神經傳導有抑制作用。

警示圖
危險性	warning
危險性警示	Not available
安全聲明	H303吞入可能有害+H313皮膚接觸可能有害+H2413吸入可能對身體有害
安全防護	P264處理后徹底清洗+P280戴防護手套/穿防護服/戴防護眼罩/戴防護面具+P305如果進入眼睛+P351用水小心沖洗幾分鐘+P338取出隱形眼鏡（如果有）并且易于操作,繼續沖洗+P337如果眼睛刺激持續+P2393獲得醫療建議/護理
備注	實驗過程中防止吸入、食入，做好安全防護

Abamectin effects on rainbow trout (Oncorhynchus mykiss) Ecotoxicology/PMID: 16570208

Abamectin induces cytotoxicity via the ROS, JNK, and ATM/ATR pathways Environmental Science and Pollution Research/PMID: 32034588

Studies revealing bioremediation potential of the strain Burkholderia sp. GB-01 for abamectin contaminated soils World Journal of Microbiology and Biotechnology/PMID: 22806778

Abamectin in the aquatic environment Ecotoxicology/PMID: 22806778

Biological and physiological responses of Perionyx excavatus to abamectin Environmental Science and Pollution Research/2019/PMID: 31368070

Acaricidal activity of spinosad and abamectin against two-spotted spider mites

Abstract

Spinosad is a bioinsecticide with a high degree of selective toxicity towards insects of different orders, but its toxicity towards the two-spotted spider mite (TSSM), Tetranychus urticae Koch (Acari: Tetranychidae) is under debate. In this study, we compared the acaricidal properties of spinosad with the commercial bioacaricide abamectin on the life stages of TSSM. Adulticide and ovicide bioassays were performed on a susceptible laboratory strain using direct spraying of leaf disks with five rates of spinosad (20, 25, 30, 35 and 40 mg/l), five rates of abamectin (0.125, 0.25, 0.5, 1 and 2.5 mg/l), sublethal concentrations or a combination of spinosad and abamectin. Both adulticidal and ovicidal effects of spinosad against T. urticae in the laboratory were apparent, based on morality rates of the adults, reduction of female fecundity and death of offspring. Abamectin was also found to significantly reduce female fecundity and killed offspring when applied directly on the eggs. Interestingly, sublethal concentrations of spinosad reduced female fecundity stronger than abamectin. When a mixture of spinosad and abamectin was applied at LC50, mortality was 74%, fecundity reduction was comparable to abamectin alone and egg hatching rate was lower than by either compound alone. In conclusion, spinosad was more harmful than abamectin for TSSM life stages and the combined application is recommended.

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