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氯菊酯

NMR下載 COA and HPLC MSDS下載
names：
Permethrin
CAS號(hào)：
52645-53-1
MDL Number： MFCD00041809
MF(分子式)： C21H20Cl2O3 MW(分子量)： 391.29
EINECS:258-067-9 Reaxys Number:52645-53-1
Pubchem ID:36845 Brand:BIOFOUNT

氯菊酯(Permethrin,52645-53-1)：純品為固體，原藥為棕黃色黏稠液體或半固體。氯菊酯有較強(qiáng)的觸殺和胃毒作用，具有擊倒力強(qiáng)、殺蟲(chóng)速度快的特點(diǎn)。對(duì)光較穩(wěn)定，在同等使用條件下，對(duì)害蟲(chóng)抗性發(fā)展也較緩慢，對(duì)鱗翅目幼蟲(chóng)高效。

貨品編碼	規(guī)格	純度	價(jià)格 (￥)	現(xiàn)價(jià)(￥)	特價(jià)(￥)	庫(kù)存描述	數(shù)量	總計(jì) (￥)
YZM000778-500mg	500mg	>98.0%	￥ 810.00	￥ 810.00		2-3天	- +	￥ 0.00
YZM000778-100mg	100mg	>98.0%	￥ 487.50	￥ 487.50		2-3天	- +	￥ 0.00

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中文別名	氯菊酯(Permethrin,52645-53-1)
英文別名	PermethrinI(氯菊酯,52645-53-1）
CAS號(hào)	52645-53-1
Inchi	InChI=1S/C21H20Cl2O3/c1-21(2)17(12-18(22)23)19(21)20(24)25-13-14-7-6-10-16(11-14)26-15-8-4-3-5-9-15/h3-12,17,19H,13H2,1-2H3
InchiKey	RLLPVAHGXHCWKJ-UHFFFAOYSA-N
分子式 Formula	C21H20Cl2O3
分子量 Molecular Weight	391.29
溶解度Solubility	生物體外In Vitro:DMSO溶解度50 mg/mL(127.78 mM;Need ultrasonic)H2O< 0.1 mg/mL(insoluble)
性狀	Solid
儲(chǔ)藏條件 Storage conditions	Pure form -20°C 3 years年 4°C 2 years年 / In solvent溶液中:-80°C 6 months月 -20°C 1 month月

氯菊酯(Permethrin,52645-53-1)毒性：

生物	測(cè)試類(lèi)型	路線	報(bào)告劑量（標(biāo)準(zhǔn)化劑量）	影響	參考
bird - domestic	LD50	oral	32gm/kg (32000mg/kg)		Defense des Vegetaux. Vol. 32, Pg. 168, 1978.
chicken	LD50	oral	7gm/kg (7000mg/kg)	BEHAVIORAL: IRRITABILITY BEHAVIORAL: TREMOR GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS	JAT, Journal of Applied Toxicology. Vol. 7, Pg. 367, 1987.
duck	LD50	oral	11300mg/kg (11300mg/kg)		Defense des Vegetaux. Vol. 32, Pg. 168, 1978.
guinea pig	LD50	oral	4gm/kg (4000mg/kg)		"Agrochemicals Handbook," with updates, Hartley, D., and H. Kidd, eds., Nottingham, Royal Soc of Chemistry, 1983-86Vol. A316, Pg. 1984,
man	LD50	unreported	> 4gm/kg (4000mg/kg)		Defense des Vegetaux. Vol. 32, Pg. 168, 1978.
man	TDLo	oral	2270mg/kg (2270mg/kg)		Journal of Toxicology, Clinical Toxicology. Vol. 36, Pg. 57, 1998.
man	TDLo	oral	2270mg/kg (2270mg/kg)	GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" BEHAVIORAL: COMA	Journal of Toxicology, Clinical Toxicology. Vol. 36, Pg. 57, 1998.
mouse	LC50	inhalation	685mg/m3 (685mg/m3)		Yakkyoku. Pharmacy. Vol. 30, Pg. 1635, 1979.
mouse	LD50	intraperitoneal	429mg/kg (429mg/kg)		Ecotoxicology and Environmental Safety. Vol. 18, Pg. 27, 1989.
mouse	LD50	intravenous	31mg/kg (31mg/kg)		Toxicology and Applied Pharmacology. Vol. 66, Pg. 153, 1982.
mouse	LD50	oral	424mg/kg (424mg/kg)		Ecotoxicology and Environmental Safety. Vol. 18, Pg. 27, 1989.
mouse	LD50	skin	> 10gm/kg (10000mg/kg)		Yakkyoku. Pharmacy. Vol. 30, Pg. 1635, 1979.
mouse	LD50	subcutaneous	10gm/kg (10000mg/kg)	BEHAVIORAL: ATAXIA BEHAVIORAL: TREMOR	Bochu Kagaku. Scientific Pest Control. Vol. 41, Pg. 143, 1976.
mouse	LD50	unreported	680mg/kg (680mg/kg)	BEHAVIORAL: COMA BEHAVIORAL: ATAXIA BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD	Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 53(9), Pg. 69, 1988.
mouse	LDLo	intracrebral	600ug/kg (0.6mg/kg)		Toxicology and Applied Pharmacology. Vol. 66, Pg. 290, 1982.
quail	LD50	oral	13500mg/kg (13500mg/kg)		Defense des Vegetaux. Vol. 32, Pg. 168, 1978.
rabbit	LD50	oral	4gm/kg (4000mg/kg)		"Agrochemicals Handbook," with updates, Hartley, D., and H. Kidd, eds., Nottingham, Royal Soc of Chemistry, 1983-86Vol. A316, Pg. 1984,
rabbit	LD50	skin	> 2gm/kg (2000mg/kg)		Farm Chemicals Handbook. Vol. -, Pg. C233, 1991.
rat	LC50	inhalation	485mg/m3 (485mg/m3)		Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 55(12), Pg. 21, 1990.
rat	LD	intravenous	> 270mg/kg (270mg/kg)		Nature. Vol. 246, Pg. 169, 1973.
rat	LD50	oral	383mg/kg (383mg/kg)		National Technical Information Service. Vol. AD-A047-284,
rat	LD50	skin	1750mg/kg (1750mg/kg)		Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 53(9), Pg. 69, 1988.
rat	LD50	subcutaneous	6600mg/kg (6600mg/kg)	BEHAVIORAL: ATAXIA BEHAVIORAL: TREMOR	Bochu Kagaku. Scientific Pest Control. Vol. 41, Pg. 143, 1976.
rat	LD50	unreported	537mg/kg (537mg/kg)	BEHAVIORAL: ATAXIA BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: COMA	Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 53(9), Pg. 69, 1988.

氯菊酯(Permethrin,52645-53-1)物理性質(zhì)：

生物	測(cè)試類(lèi)型	路線	報(bào)告劑量（標(biāo)準(zhǔn)化劑量）	影響	參考
Melting Point	34	deg C		EXP
log P (octanol-water)	6.5	(none)		EXP
Water Solubility	0.006	mg/L	20	EXP
Vapor Pressure	2.18E-08	mm Hg	25	EXP
Henry's Law Constant	1.87E-06	atm-m3/mole	25	EST
Atmospheric OH Rate Constant	3.90E-11	cm3/molecule-sec	25	EST

氯菊酯(Permethrin,52645-53-1)實(shí)驗(yàn)注意事項(xiàng)：
1.實(shí)驗(yàn)前需戴好防護(hù)眼鏡，穿戴防護(hù)服和口罩，佩戴手套，避免與皮膚接觸。
2.實(shí)驗(yàn)過(guò)程中如遇到有毒或者刺激性物質(zhì)及有害物質(zhì)產(chǎn)生，必要時(shí)實(shí)驗(yàn)操作需要手套箱內(nèi)完成以免對(duì)實(shí)驗(yàn)人員造成傷害
3.實(shí)驗(yàn)后產(chǎn)生的廢棄物需分類(lèi)存儲(chǔ)，并交于專(zhuān)業(yè)生物廢氣物處理公司處理，以免造成環(huán)境污染Experimental considerations:
1. Wear protective glasses, protective clothing and masks, gloves, and avoid contact with the skin during the experiment.
2. The waste generated after the experiment needs to be stored separately, and handed over to a professional biological waste gas treatment company to avoid environmental pollution.

Tag:氯菊酯(MSDS,氯菊酯(蒸汽壓,氯菊酯(合成,氯菊酯(標(biāo)準(zhǔn),氯菊酯(應(yīng)用,氯菊酯(合成,氯菊酯(沸點(diǎn),氯菊酯(閃點(diǎn),氯菊酯(用途,氯菊酯(溶解度,氯菊酯(價(jià)格,氯菊酯(作用,氯菊酯(結(jié)構(gòu)式,氯菊酯(用處,氯菊酯(毒理性質(zhì),氯菊酯(物理性質(zhì)）

產(chǎn)品說(shuō)明	氯菊酯(Permethrin,52645-53-1)是一種合成的擬除蟲(chóng)菊酯和神經(jīng)毒素。
Introduction	PermethrinI(氯菊酯,52645-53-1）Permethrin is a synthetic pyrethroid and neurotoxin
Application1	氯菊酯(Permethrin,52645-53-1)有較強(qiáng)的觸殺和胃毒作用，具有擊倒力強(qiáng)、殺蟲(chóng)速度快的特點(diǎn)。對(duì)光較穩(wěn)定，在同等使用條件下，對(duì)害蟲(chóng)抗性發(fā)展也較緩慢，對(duì)鱗翅目幼蟲(chóng)高效。
Application2	氯菊酯(Permethrin,52645-53-1)通過(guò)阻止鈉離子從外向內(nèi)移動(dòng)到神經(jīng)元細(xì)胞膜而影響神經(jīng)元膜，從而破壞調(diào)節(jié)膜極化的鈉通道電流。
Application3

警示圖
危險(xiǎn)性	warning
危險(xiǎn)性警示	Not available
安全聲明	H303吞入可能有害+H313皮膚接觸可能有害+H2413吸入可能對(duì)身體有害
安全防護(hù)	P264處理后徹底清洗+P280戴防護(hù)手套/穿防護(hù)服/戴防護(hù)眼罩/戴防護(hù)面具+P305如果進(jìn)入眼睛+P351用水小心沖洗幾分鐘+P338取出隱形眼鏡（如果有）并且易于操作,繼續(xù)沖洗+P337如果眼睛刺激持續(xù)+P2393獲得醫(yī)療建議/護(hù)理
備注	實(shí)驗(yàn)過(guò)程中防止吸入、食入，做好安全防護(hù)

Reaction of 2,6-dichloroquinone-4-chloroimide (Gibbs reagent) with permethrin – an optical sensor for rapid detection of permethrin in treated wood Chemistry Central Journal 2013/PMID: 23867006

Dermal absorption of permethrin following topical administration European Journal of Clinical Pharmacology 2005/PMID: 15947923

Spermiotoxicity and Embryotoxicity of Permethrin in the Sea Urchin Paracentrotus lividus Bulletin of Environmental Contamination and Toxicology 2015/PMID: 25634326

Persistence of indoor permethrin and estimation of dermal and non-dietary exposure Journal of Exposure Science & Environmental Epidemiology 2019/PMID: 30926895

Bioactivity and laundering resistance of five commercially available, factory-treated permethrin-impregnated fabrics for the prevention of mosquito-borne diseases: the need for a standa/PMID: 26738734

The pharmaceutical use of permethrin: sources and behavior during municipal sewage treatment

Abstract

Permethrin entered use in the 1970s as an insecticide in a wide range of applications, including agriculture, horticultural, and forestry, and has since been restricted. In the 21st century, the presence of permethrin in the aquatic environment has been attributed to its use as a human and veterinary pharmaceutical, in particular as a pedeculicide, in addition to other uses, such as a moth-proofing agent. However, as a consequence of its toxicity to fish, sources of permethrin and its fate and behavior during wastewater treatment are topics of concern. This study has established that high overall removal of permethrin (approximately 90%) was achieved during wastewater treatment and that this was strongly dependent on the extent of biological degradation in secondary treatment, with more limited subsequent removal in tertiary treatment processes. Sources of permethrin in the catchment matched well with measured values in crude sewage and indicated that domestic use accounted for more than half of the load to the treatment works. However, removal may not be consistent enough to achieve the environmental quality standards now being derived in many countries even where tertiary treatment processes are applied.

Spermiotoxicity and embryotoxicity of permethrin in the sea urchin Paracentrotus lividus

Abstract

The toxicity of permethrin on the fertilization and early development of sea urchin Paracentrotus lividus embryos were studied. Spermiotoxicity was evaluated on the basis of fertilization rate. Embryotoxicity was determined by comparing the frequency of normal development and malformations in embryos exposed to permethrin throughout their development. Permethrin inhibited fertilization success, and yielded IC25 and IC50 values of 0.58 (CL = 0.44-0.77) and 0.94 (CL = 0.92-0.95) µg/L, respectively. The embryotoxicity of permethrin was concentration dependent indicating a decreased percentage of normally developed plutei with increasing permethrin concentrations: IC25 = 0.195 µg/L (CL = 0.15-0.26) and IC50 = 0.346 µg/L (CF = 0.29-0.41). Associated with the decrease in normal pluteus frequency was an increase in larval malformations as skeleton deformities. The results suggest that permethrin is more highly toxic to embryos than to sperm, and that this insecticide may present a potential risk for the sea urchin in contaminated marine environments.

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