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TBE-31

NMR下載 COA and HPLC MSDS下載
names：
(4bS,8aR,10aS)-10a-ethynyl-4b,8,8-trimethyl-3,7-dioxo-3,4b,7,8,8a,9,10,10a-octahydrophenanthrene-2,6-dicarbonitrile
CAS號：
936475-62-6
MDL Number：
MF(分子式)： C21H18N2O2 MW(分子量)： 330.38
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文別名	(4bS,8aR,10aS)-10a-ethynyl-4b,8,8-trimethyl-3,7-dioxo-3,4b,7,8,8a,9,10,10a-octahydrophenanthrene-2,6-dicarbonitrile
英文別名	TBE-31; TBE 31; TBE31;
CAS號	936475-62-6
Inchi	InChI=1S/C21H18N2O2/c1-5-21-7-6-16-19(2,3)18(25)14(12-23)9-20(16,4)17(21)8-15(24)13(10-21)11-22/h1,8-10,16H,6-7H2,2-4H3/t16-,20-,21-/m0/s1
InchiKey	ISZIRXMFUSQQOS-NDXORKPFSA-N
分子式 Formula	C21H18N2O2
分子量 Molecular Weight	330.38
溶解度Solubility
性狀	Solid powder
儲藏條件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

產品說明	TBE-31(CAS:936475-62-6):僅限應用于工業或者科學研究過程中非醫療目的，不應用于人類或動物的臨床診斷以及治過程療，該產品非藥用，非食用。
Introduction	TBE-31 is a highly potent activator of Nrf2. It also acts as a potent phase 2 cytoprotective pathway inducer and liver carcinogenesis blocker.
Application1
Application2
Application3

警示圖
危險性	Warning
危險性警示
安全聲明
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備注

[1]Yao W, Zhang JC, Ishima T, Ren Q, Yang C, Dong C, Ma M, Saito A, Honda T, Hashimoto K. Antidepressant effects of TBE-31 and MCE-1, the novel Nrf2 activators, in an inflammation model of depression. Eur J Pharmacol. 2016 Dec 15;79

3:21-27. doi: 10.1016/j.ejphar.2016.10.037. Epub 2016 Nov 1. PubMed PMID: 27815170.

[3]Chan E, Saito A, Honda T, Di Guglielmo GM. The acetylenic tricyclic bis(cyano enone), TBE-31, targets microtubule dynamics and cell polarity in migrating cells. Biochim Biophys Acta. 2016 Apr;1863(4):638-49. doi: 10.1016/j.bbamcr.2016.01.008. Epub 2016 Jan 13. PubMed PMID: 26775215.

[4]Kostov RV, Knatko EV, McLaughlin LA, Henderson CJ, Zheng S, Huang JT, Honda T, Dinkova-Kostova AT. Pharmacokinetics and pharmacodynamics of orally administered acetylenic tricyclic bis(cyanoenone), a highly potent Nrf2 activator with a reversible covalent mode of action. Biochem Biophys Res Commun. 2015 Sep 25;465(3):402-7. doi: 10.1016/j.bbrc.2015.08.016. Epub 2015 Aug 8. PubMed PMID: 26265043; PubMed Central PMCID: PMC4567061.

[5] Abeti R, Uzun E, Renganathan I, Honda T, Pook MA, Giunti P. Targeting lipid peroxidation and mitochondrial imbalance in Friedreich's ataxia. Pharmacol Res. 2015 Sep;99:344-50. doi: 10.1016/j.phrs.2015.05.015. Epub 2015 Jul 2. PubMed PMID: 26141703.

5: Knatko EV, Ibbotson SH, Zhang Y, Higgins M, Fahey JW, Talalay P, Dawe RS, Ferguson J, Huang JT, Clarke R, Zheng S, Saito A, Kalra S, Benedict AL, Honda T, Proby CM, Dinkova-Kostova AT. Nrf2 Activation Protects against Solar-Simulated Ultraviolet Radiation in Mice and Humans. Cancer Prev Res (Phila). 2015 Jun;8(6):475-86. doi: 10.1158/1940-6207.CAPR-14-0362. Epub 2015 Mar 24. PubMed PMID: 25804610; PubMed Central PMCID: PMC4454593.

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