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GSK1795091

NMR下載 COA and HPLC MSDS下載
names：
O-((2R,3R,4R,5S,6R)-3-((R)-3-(decyloxy)tetradecanamido)-4-(((R)-3-(decyloxy)tetradecanoyl)oxy)-6-(hydroxymethyl)-5-(phosphonooxy)tetrahydro-2H-pyran-2-yl)-N-((R)-3-(decyloxy)tetradecanoyl)-L-serine
CAS號：
1233589-81-5
MDL Number：
MF(分子式)： C81H157N2O16P MW(分子量)： 1446.1188
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文別名	GSK1795091
英文別名	GSK1795091; GSK-1795091; GSK 1795091; CRX-601; CRX601; CRX 601;
CAS號	1233589-81-5
Inchi	InChI=1S/C81H157N2O16P/c1-7-13-19-25-31-37-40-46-52-58-69(93-61-55-49-43-34-28-22-16-10-4)64-74(85)82-72(80(88)89)68-96-81-77(83-75(86)65-70(59-53-47-41-38-32-26-20-14-8-2)94-62-56-50-44-35-29-23-17-11-5)79(78(73(67-84)97-81)99-100(90,91)92)98-76(87)66-71(60-54-48-42-39-33-27-21-15-9-3)95-63-57-51-45-36-30-24-18-12-6/h69-73,77-79,81,84H,7-68H2,1-6H3,(H,82,85)(H,83,86)(H,88,89)(H2,90,91,92)/t69-,70-,71-,72+,73-,77-,78-,79-,81-/m1/s1
InchiKey	ICLAYQQKWJGHBV-XJZMHMBSSA-N
分子式 Formula	C81H157N2O16P
分子量 Molecular Weight	1446.1188
溶解度Solubility
性狀	Solid powder
儲藏條件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

產品說明	GSK1795091(CAS:1233589-81-5):僅限應用于工業或者科學研究過程中非醫療目的，不應用于人類或動物的臨床診斷以及治過程療，該產品非藥用，非食用。
Introduction	GSK1795091, also known as CRX-601, is a potent TLR4 agonist in clinical development for the treatment of cancer. GSK1795091 binds to and activates TLR4, thereby stimulating dendritic cells (DCs), monocytes and macrophages. This activation results in the production of pro-inflammatory cytokines, including interferon gamma (IFN-g), tumor necrosis factor-alpha (TNF-a) and the interleukins (IL), IL-1 beta, -6 and -12. This may induce a T helper cell-1 (Th1) immune response and, upon co-administration of a vaccine containing tumor-associated antigens (TAAs), activates a cytotoxic T-lymphocyte (CTL) response against tumor cells expressing those TAAs. TLR4, a member of the TLR family, plays a key role in the activation of innate immunity
Application1
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[1]Oberoi HS, Yorgensen YM, Morasse A, Evans JT, Burkhart DJ. PEG modifiedliposomes containing CRX-601 adjuvant in combination with methylglycol chitosanenhance the murine sublingual immune response to influenza vaccination. J ControlRelease. 2016 Feb 10;22

3:64-74. doi: 10.1016/j.jconrel.2015.11.006. Epub 2015 Nov6. PubMed PMID: 26551346; PubMed Central PMCID: PMC4729458.

[3]Spinner JL, Oberoi HS, Yorgensen YM, Poirier DS, Burkhart DJ, Plante M, EvansJT. Methylglycol chitosan and a synthetic TLR4 agonist enhance immune responsesto influenza vaccine administered sublingually. Vaccine. 2015 Oct26;33(43):5845-5853. doi: 10.1016/j.vaccine.2015.08.086. Epub 2015 Sep 21. PubMedPMID: 26392012; PubMed Central PMCID: PMC4609623.

[4]Maroof A, Yorgensen YM, Li Y, Evans JT. Intranasal vaccination promotesdetrimental Th17-mediated immunity against influenza infection. PLoS Pathog. 2014Jan;10(1):e1003875. doi: 10.1371/journal.ppat.1003875. Epub 2014 Jan 23. PubMedPMID: 24465206; PubMed Central PMCID: PMC3900655.

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