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Amphimedine

NMR下載 COA and HPLC MSDS下載
names：
8H-Benzo(b)pyrido(4,3,2-de)(1,8)phenanthroline-8,11(10H)-dione, 10-methyl-
CAS號：
86047-14-5
MDL Number：
MF(分子式)： C19H11N3O2 MW(分子量)： 313.32
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文別名	Amphimedine
英文別名	Amphimedine
CAS號	86047-14-5
Inchi	InChI=1S/C19H11N3O2/c1-22-9-13-12(8-15(22)23)17-16-11(6-7-20-18(16)19(13)24)10-4-2-3-5-14(10)21-17/h2-9H,1H3
InchiKey	GPJKOFLDDKEODA-UHFFFAOYSA-N
分子式 Formula	C19H11N3O2
分子量 Molecular Weight	313.32
溶解度Solubility
性狀	Solid powder
儲藏條件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

產品說明	Amphimedine(CAS:86047-14-5):僅限應用于工業或者科學研究過程中非醫療目的，不應用于人類或動物的臨床診斷以及治過程療，該產品非藥用，非食用。
Introduction	Amphimedine is a Pyridoacridine Marine Alkaloid.
Application1
Application2
Application3

警示圖
危險性	Warning
危險性警示
安全聲明
安全防護
備注

[1]Khalil IM, Barker D, Copp BR. Bioinspired Syntheses of the Pyridoacridine Marine Alkaloids Demethyldeoxyamphimedine, Deoxyamphimedine, and Amphimedine. J Org Chem. 2016 Jan 4;81(1):282-9. doi: 10.1021/acs.joc.5b02312. Epub 2015 Dec 17. PubMed PMID: 26642369.

[2]Sharma V, Sharma PC, Kumar V. A mini review on pyridoacridines: Prospective lead compounds in medicinal chemistry. J Adv Res. 2015 Jan;6(1):63-71. doi: 10.1016/j.jare.2014.11.002. Epub 2014 Nov 15. Review. PubMed PMID: 25685544; PubMed Central PMCID: PMC4293674.

[3] Brahic C, Darro F, Belloir M, Bastide J, Kiss R, Delfourne E. Synthesis and cytotoxic evaluation of analogues of the marine pyridoacridine amphimedine. Bioorg Med Chem. 2002 Sep;10(9):2845-53. PubMed PMID: 12110304.

[4] Melzer B, Plodek A, Bracher F. Total synthesis of the marine pyridoacridine alkaloid demethyldeoxyamphimedine. J Org Chem. 2014 Aug 1;79(15):7239-42. doi: 10.1021/jo501312d. Epub 2014 Jul 18. PubMed PMID: 25081029.

[5] Wei X, Bugni TS, Harper MK, Sandoval IT, Manos EJ, Swift J, Van Wagoner RM, Jones DA, Ireland CM. Evaluation of pyridoacridine alkaloids in a zebrafish phenotypic assay. Mar Drugs. 2010 Jun 2;8(6):1769-78. doi: 10.3390/md8061769. PubMed PMID: 20631869; PubMed Central PMCID: PMC2901824.

6: Marshall KM, Andjelic CD, Tasdemir D, Concepción GP, Ireland CM, Barrows LR. Deoxyamphimedine, a pyridoacridine alkaloid, damages DNA via the production of reactive oxygen species. Mar Drugs. 2009 May 25;7(2):196-209. doi: 10.3390/md7020196. PubMed PMID: 19597581; PubMed Central PMCID: PMC2707043.7: Marshall KM, Barrows LR. Biological activities of pyridoacridines. Nat Prod Rep. 2004 Dec;21(6):731-51. Epub 2004 Oct 29. Review. PubMed PMID: 15565252.8: Marshall KM, Matsumoto SS, Holden JA, Concepción GP, Tasdemir D, Ireland CM, Barrows LR. The anti-neoplastic and novel topoisomerase II-mediated cytotoxicity of neoamphimedine, a marine pyridoacridine. Biochem Pharmacol. 2003 Aug 1;66(3):447-58. PubMed PMID: 12907244.9: Thale Z, Johnson T, Tenney K, Wenzel PJ, Lobkovsky E, Clardy J, Media J, Pietraszkiewicz H, Valeriote FA, Crews P. Structures and cytotoxic properties of sponge-derived bisannulated acridines. J Org Chem. 2002 Dec 27;67(26):9384-91. PubMed PMID: 12492342.

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