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Alconil

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names：
Spiro(9H-fluorene-9,4'-imidazolidine)-2',5'-dione, 2-fluoro-
CAS號：
97677-19-5
MDL Number：
MF(分子式)： C15H9FN2O2 MW(分子量)： 268.25
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文別名	Alconil
英文別名	Alconil; Al 1567; Al-1567; Al1567
CAS號	97677-19-5
Inchi	InChI=1S/C15H9FN2O2/c16-8-5-6-10-9-3-1-2-4-11(9)15(12(10)7-8)13(19)17-14(20)18-15/h1-7H,(H2,17,18,19,20)
InchiKey	JRGBXEJDIMXJAP-UHFFFAOYSA-N
分子式 Formula	C15H9FN2O2
分子量 Molecular Weight	268.25
溶解度Solubility
性狀	Solid powder
儲藏條件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

產品說明	Alconil(CAS:97677-19-5):僅限應用于工業或者科學研究過程中非醫療目的，不應用于人類或動物的臨床診斷以及治過程療，該產品非藥用，非食用。
Introduction	Alconil is a biochemical.
Application1
Application2
Application3

警示圖
危險性	Warning
危險性警示
安全聲明
安全防護
備注

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[2]Spencer K, Crossley JA, Aitken DA, Nix AB, Dunstan FD, Williams K. The effect of temporal variation in biochemical markers of trisomy 21 across the first and second trimesters of pregnancy on the estimation of individual patient-specific risks and detection rates for Down's syndrome. Ann Clin Biochem. 2003 May;40(Pt 3):219-31. PubMed PMID: 12803832.

[3] Lamensdorf I, Eisenhofer G, Harvey-White J, Nechustan A, Kirk K, Kopin IJ. 3,4-Dihydroxyphenylacetaldehyde potentiates the toxic effects of metabolic stress in PC12 cells. Brain Res. 2000 Jun 23;868(2):191-201. PubMed PMID: 10854571.

[4] Brazzell RK, Park YH, Wooldridge CB, McCue B, Barker R, Couch R, York B. Interspecies comparison of the pharmacokinetics of aldose reductase inhibitors. Drug Metab Dispos. 1990 Jul-Aug;18(4):435-40. PubMed PMID: 1976064.

[5] Park YH, McCue BA, Dobbs RE, York BM, Brazzell RK. High-performance liquid chromatographic assay of the aldose reductase inhibitor spiro-(2-fluoro-9H-fluorene-9,4'-imidazolidine)-2',5'-dione (AL01567) in plasma and urine and its pharmacokinetics in humans. J Pharm Sci. 1988 Jul;77(7):591-5. PubMed PMID: 3139862.

6: Lou MF, Dickerson JE Jr, Garadi R, York BM Jr. Glutathione depletion in the lens of galactosemic and diabetic rats. Exp Eye Res. 1988 Apr;46(4):517-30. PubMed PMID: 3133235.7: Thomas DM, Mahendroo PP, Lou MF. Dynamic phosphorus-31 NMR study of sugar cataract and its prevention in rat lenses with aldose reductase inhibitors. Exp Eye Res. 1988 Jan;46(1):37-47. PubMed PMID: 3125056.8: Griffin BW, McNatt LG, Chandler ML, York BM. Effects of two new aldose reductase inhibitors, AL-1567 and AL-1576, in diabetic rats. Metabolism. 1987 May;36(5):486-90. PubMed PMID: 3106757.9: Ohrloff C, Hockwin O, Korte I, Wegener A. [Aldose reductase inhibitor--a new way for preventing diabetic lens changes?]. Klin Monbl Augenheilkd. 1986 Nov;189(5):361-2. German. PubMed PMID: 3100860.10: Griffin BW, McNatt LG. Characterization of the reduction of 3-acetylpyridine adenine dinucleotide phosphate by benzyl alcohol catalyzed by aldose reductase. Arch Biochem Biophys. 1986 Apr;246(1):75-81. PubMed PMID: 3083781.1

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